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KMID : 0980720110300010126
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Keimyung Medical Journal
2011 Volume.30 No. 1 p.126 ~ p.130
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Cognitive Impairment in Vitamin E Deficiency Syndrome
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Yi Hyon-Ah
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Abstract
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Vitamin E deficiency syndrome, which is related to cystic fibrosis, abetalipoproteinemia, hepatobiliary abnormalities, short bowel syndrome and idiopathic causes, can have a profound effect on the nervous system. Besides hyporeflexia, ataxia, extraocular muscular disturbances, muscle weakness or blurred vision, cognitive dysfunction associated with vitamin E deficiency can be seen. A 25-year-old male presented with progressive ataxia and cognitive dysfunction for 6 months. He showed also muscular weakness, proprioceptive dysfunction on the neurological examination. Brain and spinal MRI, brain SPECT, CSF evaluation were normal. Serum vitamin E level was lower than normative value. By vitamin E supplement, muscular weakness, cognitive dysfunction were a little bit improved. We couldn’t find any causative abnormalities for vitamin E deficiency. We experienced a case of isolated vitamin E deficiency syndrome with cognitive
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KEYWORD
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Ataxia, Cognitive impairment, Vitamin E deficiency
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